Spironolactone Drug Handout
What is Spironolactone?
Spironolactone is more than just a diuretic (water pill). It does cause water loss by the kidneys but also decreases scarring within the heart muscle itself.
- Congestive heart failure in dogs and cats
- Sometimes used in advanced heart disease before congestive heart failure
- Dilated cardiomyopathy (weak heart muscle disease)
Possible Negative Effects
Please contact CVCA if your pet shows any of these signs
- Loss of appetite, vomiting or diarrhea
- Minty taste can cause drooling in cats
- Abnormal blood values – Increased potassium level or kidney values
- Itchy skin on the face is uncommon but can happen in cats
- Can be given with food and other cardiac medications
- Given once a day in cats and twice a day in dogs
- When pets are taking this medication, they need to have a blood test at least every 6 months
- Contraindicated in patients with Addison’s disease or elevated potassium levels
Interactions with Other Drugs
- Could cause high potassium levels when used with an ACEi (enalapril, benazepril)
- Can increase digoxin levels
Standard Dosage Forms
- Spironolactone Tablets – 25 mg, 50 mg, 100 mg
Synonyms: (Spironolactone, Aldactone)
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