Studies and Publications from CVCA Doctors

At CVCA Cardiac Care for Pets, we strive to provide excellent medical care.  This is not only through the daily care of our patients but also through input into the ever-growing base of knowledge of the veterinary cardiac patient.  We are proud to contribute to veterinary literature through our collaboration within our team and our veterinary academic and industry partners.


Our very own Steven Rosenthal, DVM, DACVIM (Cardiology) has co-authored a chapter in a new reference book, Clinical Small Animal Internal Medicine, edited by David Bruyette! This is a handy text for veterinary professionals and covers a wide array of clinically-relevant material!



Cardiac Studies


 Management of Heart Failure (chapter). SL Rosenthal, M Oyama. In: Bruyette, D, ed. by. Clinical Small Animal Medicine: 2 volume set. Wiley Blackwell, 2020 Mar; 1.3.19. 978-1-118-49703-6

Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study.  A Boswood, SG Gordon, SL Rosenthal, et al. Journal of Veterinary Internal Medicine. 2020 Mar; 34: 1108‐ 1118. 10.1111/jvim.15753

Echocardiographic and electrocardiographic evaluation of North American Irish Wolfhounds. WD Tyrrell, J Abbott, SL Rosenthal, M Dentino, F Abrams. Journal of Veterinary Internal Medicine. 2020 Mar; 34(2): 581–590. 10.1111/jvim.15709


Pedigree analysis of atrial fibrillation in Irish Wolfhounds supports a high heritability with a dominant mode of inheritance. SL Fousse, WD Tyrrell, ME Dentino, FL Abrams, SL Rosenthal, JA Stern. Canine Genetics and Epidemiology. 2019 Dec 9; 6:11. 10.1186/s40575-019-0079-y

A QIL1 Variant Associated with Ventricular Arrhythmias and Sudden Cardiac Death in the Juvenile Rhodesian Ridgeback Dog. KM  Meurs, SG Friedenberg, NJ Olby, J Condit, J Weidman, SL Rosenthal, GD Shelton. Genes. 2019 Feb; 10:E168.


Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets. JL Kaplan, JA Stern, AJ Fascetti, JA Larsen, H Skolnik, GD Peddle, B Lefbom, SL Rosenthal. PLoS ONE.  2018 Dec; 13:e0209112

ECG of the Month. L Kretchmer, WD Tyrrell, RE Cober. Journal of the American Veterinary Medical Association. 2018 Nov; 253(9); 1121-1124. 10.2460/javma.253.9.1121

Quiz: Hypertrophic Cardiomyopathy in Cats. A Estrada, M Boothe. Clinician’s Brief Web. 2018 Apr.

Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study. A Boswood, SG Gordon, J Häggström, G Wess, RL Stepien, SL Rosenthal, M Oyama, et al. J Vet Intern Med. 2018 Jan; 32: 72–85. 10.1111/jvim.14885


Reference intervals and allometric scaling of two-dimensional echocardiographic measurements in 150 healthy cats. S Karsten, S Savino, Y Vedat. J Vet Med Sci. 2017 Oct; 79(11). 10.1292/jvms.17-0250

ECG of the Month. M Boothe, D Newhard, R Winter. Journal of the American Veterinary Medical Association. 2017 Jun; 250(12); 1377-1378. 10.2460/javma.250.12.1377

Breed‐specific vertebral heart scale for the dachshund. R Birks, D Fine, S Leach, S Bell, et al. J Am Anim Hosp Assoc. 2017 Mar; 53:73‐79. 10.5326/JAAHA-MS-6474

Successful balloon angioplasty of pulmonary artery stenosis in two cats and associated complications. D Schrope, WD Tyrrell, K Jacob. Journal of Veterinary Cardiology. 2017; 19(6):530-537. 10.1016/j.jvc.2017.09.001


Right ventricular involvement in feline hypertrophic cardiomyopathy. KE Schober, S Savino, V Yildiz. J Vet Cardiol. 2016 Dec; 18:297‐309. 10.1016/j.jvc.2016.08.001.

Effect of Pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: the EPIC study-a randomized clinical trial. A Boswood, J Häggström, SG Gordon, SL Rosenthal, et al. J Vet Intern Med. 2016 Nov; 30(6): 1765–1779. 10.1111/jvim.14586.

Impact of collaborative care on survival time for dogs with congestive heart failure and revenue for attending primary care veterinarians. BK Lefbom, NK Peckens. Journal of the American Veterinary Medical Association. 2016 Jul; 249(1): 72-76. 10.2460/javma.249.1.72

Pentoxifylline as adjunct therapy to long-term clinical management of a right-to-left patent ductus arteriosus. E Turner. Canadian Veterinary Journal. 2016 Jun; 57(6): 655–656. PMC4866675

Ventricular arrhythmias in Rhodesian Ridgebacks with a family history of sudden death and results of a pedigree analysis for potential inheritance patterns. Kathryn M Meurs, JA Weidman, SL Rosenthal, K Lahmers, SG Friedenberg. Journal of the American Veterinary Medical Association. 2016 May; 248(10): 1135-1138. 10.2460/javma.248.10.1135


Secondary prevention of cardiogenic arterial thromboembolism in the cat: The double-blind, randomized, positive-controlled feline arterial thromboembolism; clopidogrel vs. aspirin trial (FAT CAT). DF Hogan, PR Fox, K Jacob, B Keene, NJ Laste, SL Rosenthal, et al. J Vet Cardiol. 2015 Dec; 17 (Suppl. 1):S306–17. 10.1016/j.jvc.2015.10.004

Elevated Ca2+ transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan syndrome with multiple lentigines. S Bell, TL Domeier, LM Hanft, KS Mcdonald & M Krenz. Am. J. Physiol. Heart Circ. Physiol. 2015 Feb. 308: 1086–1095 10.1152/ajpheart.00501.2014

Relationship of plasma N-terminal pro-brain natriuretic peptide concentrations to heart failure classification and cause of respiratory distress in dogs using a 2nd generation ELISA assay. PR Fox, M Oyama, MJ Hezzell, JE Rush, TP Nguyenba, B Lefbom, et al.  J Vet Intern Med. 2015 Jan; 29(1):171–179. 10.1111/jvim.12472.

NT-ProBNP And Troponin I (CTNI) levels as screening biomarkers in Irish Wolfounds. WD Tyrrell, SL Rosenthal, J Buch, M Beall, J Hanscom, F Abrams, M Dentino. J Vet Intern Med. 2015; 29:1145–1246. 10.1111/jvim.12609 


Survey of cardiac pathologies in captive striped skunks (Mephitis mephitis). L Benato, A Wack, S Cerveny, SL Rosenthal, E Bronson. Journal of Zoo and Wildlife Medicine. 2014 Jun; 45(2):321-327. 10.1638/2013-0172R1.1

Cardiac involvement secondary to mediastinal lymphoma in a cat: regression with chemotherapy. J Shih, S Brenn, D Schrope. J Vet Cardiol. 2014 Apr; 16(2): 115-120. 10.1016/j.jvc.2014.01.002.

NT-ProBNP And Troponin I levels as screening biomarkers in Great Danes. WD Tyrrell, SL Rosenthal, J Buch,  R Cahill, G Clark. J Vet Intern Med. 2014; 28:1006. 10.1111/jvim.12361


 Pharmacokinetics of oral pimobendan in healthy cats. AS Hanzlicek, R Gehring, B Kukanich, E Olson (Westphal), et al. J Vet Cardiol. 2012 Dec; 14:489‐496. 10.1016/j.jvc.2012.06.002

Emergency Presentations Associated with Cardiovascular Disease in Exotic Herbivores. R Schnellbacher, E Olson (Westphal), J Mayer, et al. Journal of Exotic Pet Medicine. 2012 Oct; 21(4):316-327. 10.1053/j.jepm.2012.09.007

Prediction of first onset of congestive heart failure in dogs with degenerative mitral valve disease: The PREDICT cohort study. D Brown, P Fox, C Reynolds, B Lefbom, K Meier, et al. J Vet Cardiol. 2012 Feb; 14(1):193-202. 10.1016/j.jvc.2012.01.008


Pharmacodynamic effects of ivabradine, a negative chronotropic agent, in healthy cats. RE Cober, KE Schober, TC Buffington, X Li, SC Riesen, JD Bonagura. J Vet Cardiol. 2011 Dec; 13(4):231-242. 10.1016/j.jvc.2011.06.001.

Multicenter Evaluation of Plasma N-Terminal Probrain Natriuretic Peptide (NT-pro BNP) as a Biochemical Screening Test for Asymptomatic (occult) Cardiomyopathy in Cats. PFox, J Rush, K Schober, M Oyama, B Lefbom, et al. Journal of Veterinary Internal Medicine. 2011 Sep; 25(5):1010-1016. 10.1111/j.1939-1676.2011.00776.x

White-coat effect on systemic blood pressure in retired racing greyhounds. CL Marino, RE Cober, MC Iazbik, CG Couto.  Journal of Veterinary Internal Medicine. 2011 May; 25:861–865. 10.1111/j.1939-1676.2011.00735.x

Utility of Cardiac Troponin I in differentiating between underlying etiologies of pericardial effusion in the canine patient. NK Peckens, M Ferguson, BK Lefbom, SL Rosenthal, WD Tyrrell. Journal of Veterinary Internal Medicine. 2011 May; 25(3):657-657. 

ECG of the Month. BG Stewart, BA Scansen, RE Cober, ME Carino. Journal of the American Veterinary Medical Association. 2011 Mar; 238(5); 572-574. 10.2460/javma.238.5.572


Assessment of serum N-terminal pro-B-type natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dogs. MA Oyama, J Rush, PR Fox, BK Lefbom, et al. Journal of the American Veterinary Medical Association. 2009 Dec; 235(11): 1319-1325. 10.2460/javma.235.11.1319.

Adverse effects of intravenous amiodarone in 5 dogs. RE Cober, KE Schober, N Hildebrandt, E Sikorska, SC Riesen. Journal of Veterinary Internal Medicine. 2009 Apr; 23(3): 657-661. 10.1111/j.1939-1676.2009.0314.x.

Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats. MA Oyama, J Rush, PR Fox, BK Lefbom, et al. Journal of Veterinary Cardiology. 2009 Apr; 11(1): S51-S61. 10.1016/j.jvc.2008.12.001.

Myocardial Infarction. K Meier, MA Oyama. Small Animal Critical Care Medicine. 2009; 41: 174-176. 10.1016/B978-1-4160-2591-7.10041-4

Beyond 2009 Studies and Publications

Non-Cardiac Studies


Surgical correction of an arteriovenous fistula in a ring-tailed lemur (Lemur catta). NC Boedeker, P Guzzetta, SL Rosenthal, LR Padilla, S Murray, K Newman. Comparative medicine. 2014 Feb;64(1):71-74. PMC3929223.

Congenital thoracic lordosis and scoliosis in a cat. MS Lee, Jim Taylor, BK Lefbom. Journal of Feline Medicine and Surgery. 2014 Jan. 10.1177/1098612X13514975.


Missense mutation in PFKM associated with muscle-type phosphofructokinase deficiency in the Wachtelhund dog. GI Gultekin, K Raj, A Hillström, S Lehman (Holdt), U Giger. Molecular and cellular probes. 2012 Dec;26(6):243-247. 10.1016/j.mcp.2012.02.004.

Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and seconday hemochromatosis in dogs. GI Gultekin, K Raj, P Foureman, S Lehman (Holdt), U Giger, O Abdulmailk. Journal of Veterinary Internal Medicine. 2012 Aug; 26(4): 935-944. 10.1111/j.1939-1676.2012.00958.x. 

Beyond 2009 Studies and Publications