Studies and Publications from CVCA Doctors

At CVCA Cardiac Care for Pets, we strive to provide excellent medical care. This is not only through the daily care of our patients but also through input into the ever-growing base of knowledge of the veterinary cardiac patient. We are proud to contribute to veterinary literature through our collaboration within our team and our veterinary academic and industry partners.

Our very own Steven Rosenthal, DVM, DACVIM (Cardiology) has co-authored a chapter in a new reference book, Clinical Small Animal Internal Medicine, edited by David Bruyette! This is a handy text for veterinary professionals and covers a wide array of clinically-relevant material!

2020s

Chyloperiardium secondary to dialysis catheter related jugular venous thrombosis in two dogs receiving long-term hemodialysis

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Woerde DJ, Palm CA, Duler L, Cowgill LD, Ames MK, Culp WTN. Front Vet Sci. 2024.

Platelet hyperresponsiveness and increased platelet-neutrophil aggregates in dogs with myxomatous mitral valve disease and pulmonary hypertension

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Duler L, Nguyen N, Johnson L, Visser LC, Li RG. JVIM. 2024.

Pacemaker-lead-associated thrombosis in dogs; a multicenter retrospective study.

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McGrath C, Dixon A, Hirst C, Bode EF, DeFrancesco T, Fries R, Gordon S, Hogan DF, Martinez Pereira Y, Mederska E, Ostenkamp S, Sykes KT, Vitt J, Payne JR. J Vet Cardiol. 2023;49:9-28.

Transvenous correction of patent ductus arteriosus in two toy-breed dogs with the Amplatzerâ„¢ Vascular Plug 4

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Ostenkamp SM, Bell SC, Hogan DF. J Vet Cardiol. 2022;44:13-17.

The longitudinal outcome of canine (K9) myxomatous mitral valve disease (LOOK-Mitral) registry: Baseline treatment characteristics

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Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology), Bill Tyrrell, DVM, Diplomate, ACVIM (Cardiology). Journal of veterinary cardiology. March 2022

Transarterial correction of patent ductus arteriosus in small dogs with the Amplatz vascular plug 4: a pilot study

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Hogan DF, Goldfeder G. J Vet Cardiol. 2021;35:48-54.

Neutrophil extracellular traps in feline cardiogenic arterial thrombi: a pilot study

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Nguyen N, Duler L, Li RH. JFMS. 2021.

Arrhythmogenic Right Ventricular Cardiomyopathy in the Bulldog: Evaluation of Clinical and Histopathologic Features, Progression, and Outcome in 71 Dogs (2004 – 2016)

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Sarah L. Holdt, VMD, Diplomate, ACVIM (Cardiology), Neal Peckens, DVM, Diplomate, ACVIM (Cardiology), Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology), Rick Cober, DVM, MS, Diplomate, ACVIM (Cardiology). Journal of Veterinary Cardiology. October 2021

A review of the underlying genetics and emerging therapies for canine cardiomyopathies

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Shen L, Estrada A, Meurs K, et al. Journal of Veterinary Cardiology. 2021.

Evaluation of radiographic predictors of left heart enlargement in dogs with known or suspected cardiovascular disease

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Duler L, Christina L. Jackson, Lance C. Visser; VRU. January 2021.

Acquired Stenosis of All Four Heart Valves in a Boxer Mix Dog

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M Boothe, SL Rosenthal. CASE. 2021 Apr; 10.1016/j.case.2021.02.005

Left atrial size and volumes in cats with primary cardiomyopathy

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Duler L, LeBlanc N, Scollan K. JVC. 2021.

Echocardiographic reference intervals with allometric scaling of 823 clinically healthy rhesus macaques (Macaca mulatta)

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Ueda Y, Duler L, Eliott KJ, Sosa PMD, Robert JA, Stern JA. BMC Vet Research. September 2020.

Identification of neutrophil extracellular traps in paraffin-embedded feline arterial thrombi using immunofluorescence microscopy

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Duler L, Nguyen N, Ontiveros E, Li RH. JoVE. March 2020.

Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study

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Adrian Boswood, Sonya G. Gordon, Steven L. Rosenthal, et al. Journal of Veterinary Internal Medicine. 2020 Mar; 34: 1108‐ 1118. 10.1111/jvim.15753

Echocardiographic and electrocardiographic evaluation of North American Irish Wolfhounds.

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William D. Tyrrell, Jr., Jonathan Abbott, Steven L. Rosenthal, Mariellen Dentino, Frances Abrams. Journal of Veterinary Internal Medicine. 2020 Mar; 34(2): 581–590. 10.1111/jvim.15709

2010s

Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

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Fox PR, Keene BW, Lamb K, et al. (Hogan DF- 9th out of 56 authors). J Vet Intern Med. 2019;33(6):2572-2586.

Comparison of metabolomics and platelet aggregometry between Plavix and generic clopidogrel in cats: a pilot study

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Malkawi M, Woolcock AD, Lee PM, Court MH, Moore GE, Hogan DF. J Feline Med Surg. 2019;21:951-958.

Pedigree analysis of atrial fibrillation in Irish Wolfhounds supports a high heritability with a dominant mode of inheritance.

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Samantha L. Fousse, William D. Tyrrell, Mariellen E. Dentino, Frances L. Abrams, Steven L. Rosenthal, Joshua A. Stern. Canine Genetics and Epidemiology. 2019 Dec 9; 6:11. 10.1186/s40575-019-0079-y

A QIL1 variant associated with ventricular arrhythmias and sudden cardiac death in the juvenile Rhodesian Ridgeback Dog.

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology), Jess Weidman, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. February 2019.

Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets; Joshua Stern, et al.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology), Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology). PLOS ONE open access. Published December 2018.

ECG of the Month.

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CVCA Doctors Involved: William Tyrrell, DVM, Diplomate, ACVIM (Cardiology), Rick Cober, DVM, MS, Diplomate, ACVIM (Cardiology). JAVMA. Published November 2018.

Hypertrophic Cardiomyopathy in Cats.

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CVCA Doctors Involved: Matthew Boothe, DVM, Resident in Cardiology. Clinician's Brief. Published April 2018.

Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study.

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. Published January 2018.

Use of n-butyl cyanoacrylate to reduce left to right shunting of an abdominal arteriovenous malformation in a dog

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Eason BD, Hogan DF, Lim C, Hogan MJ. J Vet Cardiol. 2017;19:396-403.

Aortoseptal angle and pressure gradient reduction following balloon valvuloplasty in dogs with severe subaortic stenosis

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Shen L, Estrada AH, Côté E, Powell MA, Winter B, Lamb K. Journal of Veterinary Cardiology. 2017;19:144-152.

Successful balloon angioplasty of pulmonary artery stenosis in two cats and associated complications.

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CVCA Doctors Involved: William Tyrrell, DVM, Diplomate, ACVIM (Cardiology), Kristin Jacob, DVM, Diplomate, ACVIM (Cardiology). Published December 2017. Journal of veterinary cardiology

Reference intervals and allometric scaling of two-dimensional echocardiographic measurements in 150 healthy cats.

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CVCA Doctors Involved: Stephanie Savino, DVM, Resident in Cardiology. Journal of Veterinary Medical Science. Published November 2017

ECG of the Month.

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CVCA Doctors Involved: Matthew Boothe, DVM, Resident in Cardiology. JAVMA. Published June 2017

Breed-Specific Vertebral Heart Scale for the Dachshund.

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CVCA Doctors Involved: Sarah Clay Bell, DVM, Diplomate, ACVIM (Cardiology). Journal of the American Animal Hospital Association

Right ventricular involvement in feline hypertrophic cardiomyopathy.

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CVCA Doctors Involved: Stephanie Savino, DVM, Resident in Cardiology. Journal of the Veterinary Cardiology. December 2016.

Long term management of atrial myopathy in two dogs with single chamber permanent transvenous pacemakers.

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Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study-A Randomized Clinical Trial

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. November 2016

Impact of collaborative care on survival time for dogs with congestive heart failure and revenue for attending primary care veterinarians.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology), Neal Peckens, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Medical Association. July 2016

Pentoxifylline as adjunct therapy to long-term clinical management of a right-to-left patent ductus arteriosus.

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CVCA Doctors Involved: Elizabeth Turner, DVM, Resident in Cardiology. The Canadian Veterinary Journal. June 2016

Secondary prevention of cardiogenic arterial thromboembolism in the cat: the double-blind, randomized, positive-controlled feline arterial thromboembolism; clopidogrel vs. aspirin trial (FAT CAT)

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Hogan DF, Fox PR, Jacob K, Keene B, Laste NJ, Rosenthal S, Sederquist K, Weng HY. J Vet Cardiol. 2015;17(Suppl 1)

Elevated calcium transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan Syndrome with Multiple Lentigines.

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CVCA Doctors Involved: Sarah Clay Bell, DVM, Diplomate, ACVIM (Cardiology). American Journal of Physiology — Heart and Circulatory Physiology. May 2015.

In vitro effects of the glycoprotein IIb/IIIa receptor antagonists abciximab and eptifibatide on platelet aggregation in healthy cats

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Magee AN, Hogan DF, Sederquist KA, Durham JA. Am J Vet Res. 2014;75(3):309-312.

Relationship of Plasma N-terminal Pro-brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Medicine. October 2014.

Cardiac involvement secondary to mediastinal lymphoma in a cat: regression with chemotherapy.

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CVCA Doctors Involved: Julia Shih, VMD, Diplomate, ACVIM (Cardiology). Journal of Veterinary Cardiology. June 2014.

Survey of Cardiac Pathologies in Captive Striped Skunks (Mehpitis mephitis).

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology). Journal of Zoo and Wildlife Medicine. June 2014.

Surgical correction of an arteriovenous fistula in a ring-tailed lemur (Lemur catta).

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology). Comparative Medicine. February 2014.

Congenital thoracic lordosis and scoliosis in a cat.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology). Journal of Feline Medicine and Surgery. January 2014.

Missense mutation in PFKM associated with muscle-type phosphofructokinase deficiency in the Wachtelhund dog.

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CVCA Doctors Involved: Sarah L. Holdt, VMD, Diplomate, ACVIM (Cardiology). Molecular and Cellular Probes. December 2012.

Pharmacokinetics of oral pimobendan in healthy cats.

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CVCA Doctors Involved: Emily Westphal, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Cardiology. December 2012.

Emergency Presentations Associated with Cardiovascular Disease in Exotic Herbivores.

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CVCA Doctors Involved: Emily Westphal, DVM, Diplomate, ACVIM (Cardiology). Journal of Exotic Pet Medicine. October 2012.

Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and hemochromatosis in dogs.

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CVCA Doctors Involved: Sarah L. Holdt, VMD, Diplomate, ACVIM (Cardiology. Journal of Veterinary Internal Medicine. August 2012.

Prediction of first onset of congestive heart failure in dogs with degenerative mitral valve disease: the PREDICT cohort study.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology), Katie Meier, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. February 2012.

Pharmacodynamic effects of ivabradine, a negative chronotropic agent, in healthy cats.

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CVCA Doctors Involved: Rick Cober, DVM, MS, Diplomate, ACVIM (Cardiology). Journal of Veterinary Cardiology. December 2011.

White-coat effect on systemic blood pressure in retired racing Greyhounds.

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CVCA Doctors Involved: Rick Cober, DVM, MS, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. August 2011.

ECG of the Month.

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CVCA Doctors Involved: Rick Cober, DVM, MS, Diplomate, ACVIM (Cardiology). JAVMA. March 2011.

Multicenter evaluation of plasma N-terminal probrain natriuretic peptide (NT-pro BNP) as a biochemical screening test for asymptomatic (occult) cardiomyopathy in cats.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. January 2011.

Utility of Cardiac Troponin I in differentiating between underlying etiologies of pericardial effusion in the canine patient.

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology), Bill Tyrrell, DVM, Diplomate, ACVIM (Cardiology), Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. 2011.

Utility of two point-of-care analyzers for measurement of blood lactate concentration in dogs with congestive heart failure and arterial thromboembolism: a prospective study

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology), Bill Tyrrell, DVM, Diplomate, ACVIM (Cardiology), Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. 2011.

Dose determination of fondaparinux in healthy cats

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Fiakpui NN, Hogan DF, Whittem T, Green HW III, Shipley EA, Sederquist KA. Am J Vet Res. 2012;73(4):556-561.

2000s

Assessment of serum N-terminal pro-B-type natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dogs.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology). JAVMA. December 2009

Adverse effects of intravenous amiodarone in 5 dogs.

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CVCA Doctors Involved: Rick Cober, DVM, MS, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. June 2009

Utility of plasma NT-Pro BNP to distinguish between CHF and non-cardiac causes of CHF in cats.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Cardiology. April 2009

Myocardial Infarction

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CVCA Doctors Involved: Katie Meier, DVM, Diplomate, ACVIM (Cardiology). Small Animal Critical Care Medicine. 2009

Calculation of pressure half-time.

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CVCA Doctors Involved: Jess Weidman, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Cardiology. June 2008

ECG of the Month.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology), Neal Peckens, DVM, Diplomate, ACVIM (Cardiology). JAVMA. June 2008

Endovascular retrieval of embolized jugular catheter fragments in three dogs using a nitinol gooseneck snare.

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CVCA Doctors Involved: Sara Beth Bordelon, DVM, MS, Diplomate, ACVIM (Cardiology). JAVMA. June 2008

Hyperthyroidism Associated with Probable Struma Cordis in a Young Dog.

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CVCA Doctors Involved: Emily Westphal, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. February 2008

Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency.

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology), Jennifer Sidley, DVM, Diplomate, ACVIM (Cardiology). JAVMA. October 2007

Pericardial Effusion in Cats: A Retrospective Study of Clinical Findings and Outcome in 146 Cats.

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CVCA Doctors Involved: Katie Meier, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. 2007

ECG of the Month.

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CVCA Doctors Involved: Katie Meier, DVM, Diplomate, ACVIM (Cardiology). JAVMA. November 2006

Association of pimobendan with ventricular arrhythmias in dogs with congestive heart failure.

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology), Bill Tyrrell, DVM, Diplomate, ACVIM (Cardiology), Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. May 2006

Echocardiography in a horse with cor pulmonale and right heart failure due to recurrent airway obstruction.

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CVCA Doctors Involved: Kristin Jacob, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. 2006

Aging alters regulation of visceral sympathetic nerve responses to acute hypothermia.

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CVCA Doctors Involved: Rick Cober, DVM, MS, Diplomate, ACVIM (Cardiology). American Journal of Physiology. Regulatory, integrative and comparative physiology. September 2006

Hypothermia-enhanced splenic cytokine gene expression is independent of the sympathetic nervous system.

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CVCA Doctors Involved: Rick Cober, DVM, MS, Diplomate, ACVIM (Cardiology). American Journal of Physiology. Regulatory, integrative and comparative physiology. September 2006

Ontogenetic variation in the autecology of the greater earless lizard Cophosaurus texanus.

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CVCA Doctors Involved: Katie Meier, DVM, Diplomate, ACVIM (Cardiology). Ecography. June 2006

Measurement of M-mode echocardiographic parameters in healthy adult Maine Coon cats.

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CVCA Doctors Involved: Bonnie Lefbom, DVM, Diplomate, ACVIM (Cardiology), Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology), William Tyrrell, DVM, Diplomate, ACVIM (Cardiology). JAVMA. March 2005

The road to identifying the juvenile hormone membrane receptor: pharmacological studies on ovarial patency in Heliothis virescens.

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Pestycydy. 2005

Corticosteroid-Associated Congestive Heart Failure in 12 Cats.

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CVCA Doctors Involved: Kristin Jacob, DVM, Diplomate, ACVIM (Cardiology). Internal Journal of Applied Research in Veterinary Medicine. 2004

Noninvasive transthoracic temporary pacing in dogs.

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CVCA Doctors Involved: Jennifer Sidley, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. September 2003

Use of pericardial fluid pH to distinguish between idiopathic and neoplastic effusions.

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CVCA Doctors Involved: Kristin Jacob, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. August 2003

Arterial Thromboembolism in Cats: Acute Crisis in 127 Cases (1992-2001) and Long-Term Management with Low-Dose Aspirin in 24 Cases.

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CVCA Doctors Involved: Kristin Jacob, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. February 2003

Percutaneous balloon pericardiotomy as a treatment for recurrent pericardial effusion in 6 dogs.

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CVCA Doctors Involved: Jennifer Sidley, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. October 2002

Supravalvular mitral stenosis in a cat.

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CVCA Doctors Involved: Kristin Jacob, DVM, Diplomate, ACVIM (Cardiology). Journal of the American Animal Hospital Association. September - October 2002

Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation.

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CVCA Doctors Involved: Steven Rosenthal, DVM, Diplomate, ACVIM (Cardiology), Jennifer Sidley, DVM, Diplomate, ACVIM (Cardiology). JAVMA. September 2002

Natural history of hypertrophic cardiomyopathy and aortic thromboembolism in a family of domestic shorthair cats.

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CVCA Doctors Involved: Jennifer Sidley, DVM, Diplomate, ACVIM (Cardiology). Journal of Veterinary Internal Medicine. December 2001

Heartworm infection in cats: 50 cases (1985-1997).

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CVCA Doctors Involved: Jennifer Sidley, DVM, Diplomate, ACVIM (Cardiology). JAVMA. August 2000

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